PhD Student

Course Start: March 2017

Supervisor: Dr Daniel Bailey
Second Supervisor: Dr Julia Fruer

Working Thesis Title

“Impact of sedentary time on cardiometabolic health in South Asian adults”

Abstract

South Asians have significantly higher mortality and prevalence rate of CVD and Type 2 diabetes compared to the general populations in the UK (Fischbacher, Hunt and Alexander, 2004). South Asians are at two to six times higher risk of developing Type 2 diabetes compared to Caucasians in the UK (Hanif and Susarla, 2018). Another study reported that the prevalence of Type 2 diabetes in UK South Asians is nearly 20% which is approximately fivefold higher compared to Caucasians (Gholap et al., 2011). In addition, South Asians are genetically at risk of developing cardiometabolic disease compared to the general populations living in the UK, possibly due to having several risk markers including lower plasma vitamin C concentration, lower concentration of vitamin D, high level of visceral and hepatic fat, and higher C-reactive protein level (Sattar, Wannamethee and Forouhi, 2008). Previous finding suggested that standardised mortality ratios (SMR) for ischaemic heart disease was highest in UK South Asians compared to the Caucasians and African-Caribbean adults (Chaturvedi, 2003). In addition, evidence suggests that the rate of CVD was about 30–40% higher among South Asians than Caucasians in the UK, but the reason behind it is unknown (Sproston and Mindell, 2006).

Previous experimental findings suggested that breaking up prolonged sitting every 20-30 min with light or moderate intensity activities reduce cardiometabolic risk markers including post prandial glucose concentration in healthy, normal weight, and overweight and obese Caucasian adults (Henson et al., 2016; Peddie et al., 2013; Dunstan et al., 2012; Bailey and Locke, 2015).However, the effects of breaking up sitting on cardiometabolic risk markers in normal weight versus overweight and obese South Asians are unknown. Therefore, this study needs to be conducted to examine the effects on breaking up prolonged sitting on cardiometabolic health in normal weight versus overweight and obese South Asian adults.

Research design and setting

This study is a two-condition and two-groups (overweight and obese vs normal-weight) randomised cross over the trial and it will be conducted at the Sport and Exercise Science Laboratories at the University of Bedfordshire.The study will follow the following experimental protocol. 1. Prolongedsitting (SIT):Participants will remain seated for 5 h. 2.Breaking up sitting with walking breaks (INT-SIT):Participants will rise from the seated position every 30 min throughout the experimental period to walk on a motorised treadmillat a light intensity walking for 3 min.

This study will identify a simple physical activity intervention to reduce cardiometabolic disease risk in South Asians. Predictively,  introducing breaking up sitting time after a meal could reduce cardiometabolic risk markers (postprandial glucose, blood pressure and lipids including triglycerides and HDL), which could ultimately reduce the risk of CVD and Type 2 diabetes in this population. This research study could lead to the development of a long term public health intervention to reduce prolonged sitting and the national burden of CVD and Type 2 diabetes in South Asians living in the UK.

Research Questions

• What is the acute effect of breaking up prolonged sitting on postprandial cardiometabolic disease risk makers in normal weight versus overweight/obese South Asian adults?

Education Background

• MBA in Hospital and Health Services Management, University of Bedfordshire, UK
• MSc in Public Health, University of Bedfordshire, UK
• BSc in Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Bangladesh

Membership of Professional Bodies

• The Royal Society of Health and The Royal Institute of Public Health, UK
• Faculty of Public Health, UK
• PHAST, UK

Publications

• Dey, K.C., Begum, R., Rahman, M.R.T., Sultana, A., Akter, S. & Janny, R.J. (2014) 'Development of Fruit Juice Yogurt by Utilization of Jackfruit Juice: A Preliminary Study on Sensory Evaluation, Chemical Composition and Microbial Analysis', International Journal of Engineering Research & Technology (IJERT), 3 (4), pp.1074-1079.
• Chen, W., Li, X., Rahman, M.R.T., Al-Hajj, N.Q.M., Dey, K.C. & Raqib, S.M. (2014) 'Emulsification properties of soy bean protein', Nusantara Bioscience, 6 (2), pp.196-202.

Contact Information

M: 07574748607
E: kamalesh.dey@study.beds.ac.uk
Twitter: @kamalesh_dey
Linkedin: Kamalesh Dey
ResearchGate